:root{color-scheme:light;--ink:#112b32;--muted:#586e71;--green:#165b52;--line:#d7e1dd;--wash:#eff5f1;--paper:#fff;}
*{box-sizing:border-box}body{margin:0;color:var(--ink);background:#f8faf9;font-family:Georgia,'Times New Roman',serif;line-height:1.72;font-size:17px}
a{color:#11685f;text-underline-offset:3px}a:hover{text-decoration-thickness:2px}
header.top{border-bottom:1px solid var(--line);background:#fff}header .nav{max-width:1160px;margin:auto;padding:18px 25px;display:flex;justify-content:space-between;align-items:center;gap:12px}
.brand{font:750 13px/1.3 Arial,sans-serif;letter-spacing:.13em;color:var(--green);text-decoration:none}.nav a.secondary{font:600 13px Arial,sans-serif;text-decoration:none}
main{max-width:1160px;margin:auto;padding:38px 25px 110px}.hero{padding:45px 0 43px;border-bottom:1px solid var(--line)}.eyebrow{font:700 12px Arial,sans-serif;letter-spacing:.14em;text-transform:uppercase;color:var(--green)}
h1{font-size:clamp(36px,5vw,60px);line-height:1.14;letter-spacing:-.028em;margin:16px 0 18px;max-width:900px}h2{font-size:30px;line-height:1.2;letter-spacing:-.02em}h3{font-size:21px;line-height:1.3;margin:34px 0 10px}.hero p{max-width:790px;color:#334d50;font-size:19px}
.metadata{font:500 13px/1.6 Arial,sans-serif;color:var(--muted)}.pill{display:inline-block;background:var(--wash);padding:7px 12px;border-radius:2px;font:700 11px Arial,sans-serif;color:var(--green);letter-spacing:.07em;margin:2px 5px 5px 0}
.toolbar{background:white;border:1px solid var(--line);padding:15px 18px;margin:24px 0;font:600 13px Arial,sans-serif}.toolbar a{margin-right:24px}
.search{border:1px solid #a8bcb5;background:white;width:100%;padding:15px 18px;font:16px Arial,sans-serif;max-width:700px;margin:15px 0 20px}
.series{margin:42px 0}.series h2{border-bottom:1px solid var(--line);padding-bottom:15px;margin-bottom:14px}.papers{display:grid;grid-template-columns:repeat(auto-fit,minmax(290px,1fr));gap:15px}.paper-card{background:white;border:1px solid var(--line);padding:19px 20px 17px;min-height:170px}.paper-card:hover{border-color:#87aea2}
.paper-card .number{font:700 12px Arial,sans-serif;color:var(--green)}.paper-card h3{font-size:19px;margin:10px 0}.paper-card a{color:var(--ink);text-decoration:none}.paper-card a:hover{text-decoration:underline}.paper-card .desc{font:13px/1.5 Arial,sans-serif;color:var(--muted)}
.article{background:#fff;max-width:900px;margin:0 auto;padding:32px 42px 75px;border:1px solid var(--line)}.article h1{font-size:clamp(34px,4vw,49px)}.article h2{font-size:23px;margin:35px 0 8px}.article p{margin:0 0 18px}.article h2+p{margin-top:0}.article .abstract{border-left:3px solid #1c7065;padding:2px 0 0 20px;color:#294748}.article .abstract p{font-size:17px}
.reference{font:14px/1.7 Arial,sans-serif;overflow-wrap:anywhere;margin:0 0 10px}.source{font:13px/1.65 Arial,sans-serif;color:var(--muted);border-top:1px solid var(--line);padding-top:22px;margin-top:35px}.medical-note{background:#f1f5f3;border-left:3px solid #9bb8ab;padding:12px 16px;font:13px/1.6 Arial,sans-serif;color:#486160;margin-top:30px}.breadcrumb{font:12px Arial,sans-serif;margin-bottom:20px}.foot{font:12px/1.8 Arial,sans-serif;color:var(--muted);padding-top:38px;max-width:900px;margin:auto}
@media(max-width:700px){main{padding:20px 14px 65px}.article{padding:25px 19px 55px}.hero{padding:20px 0 30px}body{font-size:16px}.toolbar a{display:inline-block;margin:4px 10px 4px 0}}